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Comparative In Vivo Inhibitory Effects of Nonsteroidal Anti-inflammatory Agents on Prostaglandin Synthesis in Rabbit Ocular Tissues
Prasad S. Kulkarni, PhD;
B. Dobli Srinivasan, MD, PhD
Arch Ophthalmol. 1985;103(1):103-106.
Abstract
• We have compared the effects of nonsteroidal anti-inflammatory agents (NSAIDs) indomethacin, flurbiprofen, and aspirin administered either intraperitoneally (IP) or topically on rabbit conjunctival and anterior uveal prostaglandin (PG) synthesis. Doses of IP flurbiprofen and aspirin at or above 50 mg/kg almost completely inhibited PG synthesis in the conjunctiva and anterior uvea. Indomethacin at doses up to 100 mg/kg only partially inhibited PG synthesis in rabbit anterior uvea. Although IP flurbiprofen and aspirin were better than IP indomethacin in inhibiting PG synthesis in anterior uvea, 0.5% topical aspirin almost completely inhibited PG synthesis in the conjunctiva and anterior uvea, but 0.5% flurbiprofen and 0.5% indomethacin did not. A lower topical dose (0.01%) of aspirin prevented the production of PGs in the anterior uvea.
Author Affiliations
From the Department of Ophthalmology (Drs Kulkarni and Srinivasan), College of Physicians and Surgeons, Columbia University, New York.
Footnotes
Accepted for publication July 26, 1984.
Reprint requests to Columbia University, 630 W 168th St, New York, NY 10032 (Dr Kukarni).
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