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IV. Comparison of Povidone-Iodine on the Conjunctiva With a Prophylactic Antibiotic

Sherwin J. Isenberg, MD; Leonard Apt, MD; Robert Yoshimori, PhD; Steven Khwarg, MD

Arch Ophthalmol. 1985;103(9):1340-1342.

Abstract
• We previously found that half-strength (5%) povidone-iodine solution significantly reduced the bacterial flora of the conjunctiva. To compare the antibacterial effect of a topical combination antibiotic (Neosporin ophthalmic solution) given three times daily for three days preoperatively with that of half-strength povidone-iodine solution given as part of the preoperative preparation, conjunctival cultures were studied from 35 patients undergoing ocular surgery. When used individually, the antibiotic and povidone-iodine solutions caused a similar and substantial decrease in the number of colonies and species of bacteria cultured. When both drugs were used together, the decrease was even more striking, making 83% of the conjunctivae sterile. To minimize bacterial flora before ocular surgery, we recommend that a broad-spectrum topical antibiotic be given for three days preoperatively and that half-strength povidone-iodine solution be used as part of the preoperative preparation.

Author Affiliations
From the Jules Stein Eye Institute, Division of Ophthalmology, Harbor-UCLA Medical Center, Torrance, Calif (Drs Isenberg and Yoshimori); and the Department of Ophthalmology, UCLA School of Medicine, Los Angeles (Drs Isenberg, Apt, and Khwarg).

Footnotes
Accepted for publication April 1, 1985.

Reprint requests to Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA 90024 (Dr Isenberg).

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