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A Comparison in Patients With Keratoconjunctivitis Sicca

J. Daniel Nelson, MD; R. Linsy Farris, MD

Arch Ophthalmol. 1988;106(4):484-487.

Abstract
• An unpreserved artificial tear substitute containing 0.1% sodium hyaluronate was compared with a preparation containing 1.4% polyvinyl alcohol and 0.5% chlorobutanol in a controlled, double-masked, randomized study in patients with moderately severe keratoconjunctivitis sicca. Patients were evaluated initially, at 1, 4, and 8 weeks. The dry-eye status was evaluated by means of tear-film osmolality, tear breakup time, rose bengal staining, Schirmer's test (without anesthesia), and ocular surface-impression cytology. In general, neither preparation was found to be superior to the other. In both study groups, the mean tear-film osmolality and rose bengal staining score improved over the eight-week study, but the degree of squamous metaplasia of the bulbar conjunctival surface, as shown by impression cytology, did not change significantly.

Author Affiliations
From the Departments of Ophthalmology, St Paul-Ramsey Medical Center, St Paul and the University of Minnesota, Minneapolis (Dr Nelson); and Columbia University, New York (Dr Farris).

Footnotes
Accepted for publication Nov 24, 1987.

Reprint requests to Department of Ophthalmology, St. Paul-Ramsey Medical Center, 640 Jackson St, St Paul, MN 55101 (Dr Nelson).

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