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Preliminary Results of the First 7 Human Cases

Mee Kum Kim, MD; Jae Lim Lee, MD; Won Ryang Wee, MD; Jin Hak Lee, MD

Arch Ophthalmol. 2002;120:761-766.

Objective  To evaluate the clinical efficacy of a newly designed Seoul-type keratoprosthesis (S-KPro).

Methods  The S-KPro, which consists of a polymethyl methacrylate optic, a skirt (polyurethane or polypropylene), and polypropylene haptics, was developed and implanted into 2 unsighted and 5 sighted eyes of 7 patients. One patient had a chemical burn, another had an ocular pemphigoid, and the remainder were diagnosed as having Stevens-Johnson syndrome. The preoperative visual acuities ranged from light perception to hand motions. The average follow-up time was 25.6 months.

Main Outcome Measures  We evaluated anatomical stability, visual acuity, retinal status, and the visual field.

Results  At the last follow-up visit, the S-KPro was well placed in 6 patients. The best-corrected visual acuities of the sighted patients ranged from 20/100 to 20/60 in the affected eye. One patient each experienced retinal detachment or endophthalmitis. Partial extrusion was found in the patient with glaucoma. A retroprosthetic membrane was detected in 1 patient and was treated with an Nd:YAG laser. No glaucomatous visual field defects were found in any of the sighted patients.

Conclusions  Anatomical success was achieved in 6 of 7 eyes. In 3 of the 5 sighted eyes, the S-KPro could rehabilitate corneal blindness not correctable with keratoplasty.

From the Departments of Ophthalmology, Seoul Municipal Boramae Hospital, Seoul (Dr Kim), Chungnam National University Hospital, Taejon (Dr J. L. Lee), and Seoul National University College of Medicine and Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Center, Seoul (Drs Wee and J. H. Lee), Korea.

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