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The Cardiovascular Health Study

Gabriella Tikellis, PhD; Cong Sun, MD, MPH; Michael B. Gorin, MD, PhD; Ronald Klein, MD, MPH; Barbara E. K. Klein, MD, MPH; Emily K. Marino Larsen, MS; David S. Siscovick, MD, MPH; Larry D. Hubbard, MAT; Tien Y. Wong, MD, PhD

Arch Ophthalmol. 2007;125(1):68-73.

Objective  To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population.

Methods  Two thousand one hundred seventy persons 65 years and older sampled from 4 US communities had ARM signs assessed from retinal photographs using a modified Wisconsin Age-Related Maculopathy Grading System. DNA extracted from blood samples was analyzed for common APOE alleles.

Results  After controlling for age, sex, cigarette smoking, and other factors, white participants carrying the 2 allele had an increased risk of late ARM (odds ratio, 2.53 [95% confidence interval, 1.08-5.90]) while carriers of the 4 allele had a lower risk of late ARM (odds ratio, 0.69 [95% confidence interval, 0.19-2.50]). There were too few late ARM cases in African American individuals for analysis.

Conclusion  APOE polymorphism is associated with late ARM in older white persons 65 years and older. Consistent with previous studies, the APOE 2 allele is associated with a significant increased risk of late ARM development, whereas the 4 allele may confer some protection.

Author Affiliations: Centre for Eye Research Australia, University of Melbourne, Victoria (Drs Tikellis, Sun, and Wong); Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pa (Dr Gorin and Mr Hubbard); Department of Ophthalmology, University of Wisconsin, Madison (Drs R. Klein and B. E. K. Klein); Departments of Biostatistics (Ms Larsen) and Medicine and Epidemiology (Dr Siscovick), University of Washington, Seattle; Singapore Eye Research Institute, National University of Singapore, Singapore (Dr Wong).

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