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A Multicenter, Randomized Clinical Trial of Intraocular Antibiotic Injection, Report 2

Masoud Soheilian, MD; Nasrin Rafati, MD; Mohammad-Reza Mohebbi, PhD; Shahin Yazdani, MD; Houshang Faghihi Habibabadi, MD; Mostafa Feghhi, MD; Hossein A. Shahriary, MD; Jamil Eslamipour, MD; Niloofar Piri, MD; Gholam A. Peyman, MD; for the Traumatic Endophthalmitis Trial (TET) Research Group

Arch Ophthalmol. 2007;125(4):460-465.

Objective  To evaluate the efficacy of intraocular gentamicin sulfate and clindamycin in the prevention of acute posttraumatic bacterial endophthalmitis following penetrating eye injuries.

Method  We conducted a multicenter, randomized, double-masked controlled trial of 346 eyes with penetrating eye injury. Following primary repair, eyes were randomized to intracameral or intravitreal injection of 40 µg of gentamicin sulfate and 45 µg of clindamycin (cases) vs balanced salt solution (controls).

Main Outcome Measure  Occurrence of endophthalmitis within 2 weeks.

Results  Endophthalmitis occurred in 8 (2.3%) of 167 eyes in the control group and only in 1 (0.3%) of 179 eyes in the case group (P = .04; odds ratio, 8.93 [95% confidence interval, 1.11-71.43]). In eyes with an intraocular foreign body, endophthalmitis developed in 7 of 25 control eyes and in none of 27 eyes receiving antibiotics. However, in eyes without an intraocular foreign body, endophthalmitis developed in 1 of 142 eyes and 1 of 152 eyes in the 2 groups, respectively (P value for interaction = .04). Intravitreal injection was superior to intracameral injection in preventing endophthalmitis (P value for interaction = .01). Vitreous culture results were positive in 6 (67%) of 9 eyes with endophthalmitis.

Conclusion  Intraocular gentamicin and clindamycin are effective in the prevention of acute posttraumatic bacterial endophthalmitis in eyes with retained intraocular foreign body.

Application to Clinical Practice  Prophylaxis of traumatic endophthalmitis.

Trial Registration  clinicaltrials.gov Identifier: NCT00398658

Author Affiliations: Department of Ophthalmology and Ophthalmic Research Center, Labbafinejad Medical Center, Shaheed Beheshti University of Medical Sciences (Drs Soheilian, Rafati, Mohebbi, Yazdani, and Eslamipour), Negah Eye Hospital (Drs Soheilian, Rafati, and Yazdani), and Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences (Drs Faghihi Habibabadi and Piri), Tehran, Iran; Department of Ophthalmology, Sina General Hospital, Ahwaz University of Medical Sciences, Ahwaz, Iran (Dr Feghhi); Department of Ophthalmology, Alzahra Hospital, Zahedan University of Medical Sciences, Zahedan, Iran (Dr Shahriary); and Department of Ophthalmology, Tulane Health Science Center, New Orleans, La (Dr Peyman).

RELATED LETTERS

Prophylaxis of Acute Posttraumatic Bacterial Endophthalmitis: A Multicenter, Randomized Clinical Trial of Intraocular Antibiotic Injection, Report 2
Masoud Soheilian, Nasrin Rafati, Mohammad-Reza Mohebbi, Shahin Yazdani, Houshang Faghihi Habibabadi, Mostafa Feghhi, Hossein A. Shahriary, Jamil Eslamipour, Niloofar Piri, Gholam A. Peyman, and for the Traumatic Endophthalmitis Trial (TET) Research Group
Arch Ophthalmol. 2007;125(4):460-465.
ABSTRACT | FULL TEXT  

Toxicity of Intraocular Gentamicin
Brice Dille
Arch Ophthalmol. 2007;125(10):1442.
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Toxicity of Intraocular Gentamicin—Reply
Masoud Soheilian, Nasrin Rafati, Shahin Yazdani, and for the Traumatic Endophthalmitis Trial (TET) Research Group
Arch Ophthalmol. 2007;125(10):1442-1443.
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Prophylaxis for Posttraumatic Endophthalmitis
Rohan W. Essex, Ecosse Lamoureux, Patrick G. P. Charles, and Penny Allen
Arch Ophthalmol. 2008;126(5):742-743.
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Prophylaxis for Posttraumatic Endophthalmitis—Reply
Masoud Soheilian, Nasrin Rafati, Shahin Yazdani, and for the Traumatic Endophthalmitis  Trial (TET) Research Group
Arch Ophthalmol. 2008;126(5):743-744.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Prophylaxis for Posttraumatic Endophthalmitis
Essex et al.
Arch Ophthalmol 2008;126:742-743.
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Prophylaxis for Posttraumatic Endophthalmitis--Reply
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Arch Ophthalmol 2008;126:743-744.
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Toxicity of Intraocular Gentamicin
Dille
Arch Ophthalmol 2007;125:1442-1442.
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Toxicity of Intraocular Gentamicin Reply
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Arch Ophthalmol 2007;125:1442-1443.
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