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IV. Effect of Vasodilating Agents

Suresh R. Chandra, MD; Ephraim Friedman, MD

Arch Ophthalmol. 1979;97(7):1331-1332.

Abstract
• The effect of vasodilators on choroidal blood flow (CBF) was studied by the krypton clathrate Kr 85 desaturation technique in anesthetized cats. Niacin, papaverine hydrochloride, phentolamine mesylate, and tolazoline hydrochloride were injected via the lateral long posterior ciliary artery (LLPCA) and the femoral artery. The systemic administration of these drugs via the femoral artery, in the doses used, had no significant effect on mean arterial pressure, choroidal vascular resistance (CVR), or CBF. Local administration of the same agents via the LLPCA caused a decrease in CVR with a corresponding increase in CBF.

Author Affiliations
From the Massachusetts Lions Eye Research Laboratory, Department of Ophthalmology, Boston University School of Medicine. Dr Chandra is now with the Department of Ophthalmology, University of Wisconsin Medical School, Madison, and Dr Friedman is now with Albert Einstein College of Medicine, Bronx, NY.

Footnotes
Accepted for publication July 28, 1978.

Reprint requests to Department of Ophthalmology, Clinical Science Center, 600 Highland Ave, Madison, WI 53792 (Dr Chandra).

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