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Arch Ophthalmol. 1999;117(4):522-523.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

ARCHIVES OF GENERAL PSYCHIATRY

Smooth Pursuit Eye Movements to Extraretinal Motion Signals: Deficits in Relatives of Patients With Schizophrenia

Gunvant K. Thaker, MD; David E. Ross, MD; Shawn L. Cassady, MD; Helene M. Adami, MSW; David LaPorte, PhD; Deborah R. Medoff, PhD; Adrienne Lahti, MD

Background: Although mounting evidence supports the idea that smooth pursuit abnormality marks the genetic liability to schizophrenia, the precise ocular motor mechanism underlying the abnormality remains unknown. Based on recent findings in schizophrenia, we hypothesize that subtle deficits in the ability to hold online and/or use extraretinal motion information underlie the pursuit abnormality in vulnerable individuals.

Methods: The hypothesis was tested in 69 first-degree, biological relatives of probands with schizophrenia; 26 relatives had schizophrenia spectrum personalities (SSP). Subjects recruited from the community (n=71; 29 with SSP), without a known family history of psychosis, constituted the comparison groups. The traditional smooth pursuit gain measure, which is . . . [Full Text of this Article]