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Visual Improvement in an Adult Amblyopic Eye Following Radiation-Induced Visual Loss in the Contralateral Eye
Arch Ophthalmol. 2004;122:126-128.
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Amblyopia is a visual deficit defined as decreased best-corrected visual acuity of at least a 2-line difference between the two eyes that is not due to an organic cause.1 It is typically associated with strabismus, uncorrected asymmetric refractive error, or ocular disorders that interfere with the development of the fixation reflex. Although the pathophysiological mechanisms in amblyogenesis are not completely understood, a fundamental principle of treatment is that therapy can be effective only when the visual system is sufficiently "plastic" for cortical modification to occur. The sensitive or critical period of visual development and modification is species specific and age defined; in humans it is thought to occur from birth to the arbitrary age of 9 years.1
We describe an adult with a childhood history of anisometropic amblyopia who lost central vision in his dominant eye as a result of radiation-induced maculopathy following treatment for a macular choroidal melanoma. The . . . [Full Text of this Article] Report of a Case
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Ekaterini C. Karatza, MD;
Carol L. Shields, MD;
Jerry A. Shields, MD
Philadelphia, Pa
Corresponding author and reprints: Carol L. Shields, MD, Oncology Service, Wills Eye Hospital, 840 Walnut St, Philadelphia, PA 19107.
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