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Effects of Intravitreous Injection of Preserved and Nonpreserved Triamcinolone in Rabbit Retina—Reply
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In reply
We thank Carvounis and colleagues for their letter and insightful questions regarding our research.1 Intravitreal injection of triamcinolone is emerging as a promising new treatment of diabetic macular edema and age-related retinal degeneration. We agree that it is crucial and urgent to elucidate the possible retinal toxicity of this treatment.
We found that triamcinolone-injected rabbit eyes showed increased rod-mediated electroretinography (ERG) b-wave amplitudes when compared with the control eyes. Multivariate analysis of variance was performed to determine significant differences between the 3 groups. Differences were measured by using the Bonferroni correction, which requires that the stated  , desired to be constant across all comparisons, be divided by the number of comparisons to derive a cutoff value. This value must be attained by each comparison before it can be considered more than a chance result among the multiple comparisons. However, this process was unforgivably not executed during our data . . . [Full Text of this Article]
AUTHOR INFORMATION
Dustin Dierks, MD;
Bo Lei, PhD;
Keqing Zhang, BS;
Dean P. Hainsworth, MD
RELATED LETTER
Effects of Intravitreous Injection of Preserved and Nonpreserved Triamcinolone in Rabbit Retina
Petros E. Carvounis, Muhammad Abd El Barr, Thomas A. Albini, and Eric R. Holz
Arch Ophthalmol. 2006;124(11):1666.
EXTRACT
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RELATED ARTICLE
Electroretinographic Effects of an Intravitreal Injection of Triamcinolone in Rabbit Retina
Dustin Dierks, Bo Lei, Keqing Zhang, and Dean P. Hainsworth
Arch Ophthalmol. 2005;123(11):1563-1569.
ABSTRACT
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