 |
|
Evaluating the Cryotherapy for Retinopathy of Prematurity Study (CRYO-ROP)
Monte D. Mills, MD
Arch Ophthalmol. 2007;125(9):1276-1281.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
The Multicenter Trial of Cryotherapy for Retinopathy of Prematurity Study (CRYO-ROP) remains one of the largest investigations ever organized for a pediatric ophthalmic disease. Spanning more than 20 years so far, and involving hundreds of ophthalmologists, neonatologists, photographers, visual acuity testers, and other investigators in 23 clinical centers across the United States, this gargantuan effort has produced high-quality data about the benefits of treatment of retinopathy of prematurity (ROP) with peripheral retinal ablation as well as the natural history of ROP and the development and measurement of visual function in young children with developmental and visual impairment. In addition, this trial led to innovations in the design and organization of randomized interventional trials that have gained wide acceptance and application in other fields.
What is the best measure of the success of a clinical trial? Formally, trials must be judged first on the ability to achieve . . . [Full Text of this Article] STUDY GOALS
STUDY DESIGN
Patient Selection and Randomization Treatment Methods Outcome Measures Ethical Considerations Statistical Measures
STUDY RESULTS
Primary Outcome Measures
Secondary Outcome Measures Natural History Control Outcomes
STUDY CONCLUSIONS AND RECOMMENDATIONS
INFLUENCE OF THE STUDY ON SUBSEQUENT CLINICAL INVESTIGATIONS
INFLUENCE OF THE STUDY ON CLINICAL PRACTICE IN MANAGEMENT OF ROP
AUTHOR INFORMATION
|
