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COMMENTS AND OPINIONS
Potential Causes of Altered Autofluorescence in Diabetic Persons—Reply
Matthew G. Field, BA;
Victor M. Elner, MD, PhD;
Jason M. Feuerman, BS;
John R. Heckenlively, MD;
Howard R. Petty, PhD
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In reply
We agree with Dr Spaide that the noninvasive analysis of retinal FA in humans cannot eliminate contributions from certain other autofluorescence molecules. However, several lines of evidence support our interpretation that the FA signal to noise ratio is sufficient to detect the differences in contrast in this and other studies.1-3
Cataracts were limited to early nuclear sclerosis, principally in a few older patients; 2 diabetic patients had had focal laser treatment outside the central macula. Thus, these were unlikely to account for the FA differences between age-matched controls and 20 of 21 diabetic patients who had elevated FA.
We are aware of Delori et al,4 who used a spectroscopic method that detected an unknown minor fluorophore with a peak emission between 520 to 540 nm that was . . . [Full Text of this Article]
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Rapid, Noninvasive Detection of Diabetes-Induced Retinal Metabolic Stress
Matthew G. Field, Victor M. Elner, Donald G. Puro, Jason M. Feuerman, David C. Musch, Rodica Pop-Busui, Richard Hackel, John R. Heckenlively, and Howard R. Petty
Arch Ophthalmol. 2008;126(7):934-938.
ABSTRACT
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RELATED LETTER
Potential Causes of Altered Autofluorescence in Diabetic Persons
Richard F. Spaide
Arch Ophthalmol. 2009;127(7):942-943.
EXTRACT
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