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COMMENTS AND OPINIONS
Pathogenesis of Nonarteritic Anterior Ischemic Optic Neuropathy
Sohan Singh Hayreh, MD, PhD, DSc, FRCS, FRCOphth
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In their article,1 Levin and Danesh-Meyer contend that, in nonarteritic anterior ischemic optic neuropathy (NAION), "in many cases the ischemia results from venous congestion."
Since 1955 I have conducted extensive multifaceted studies on the blood supply and anatomy of the optic nerve as well as experimental and prospective clinical studies on various aspects of NAION (on more than 1000 patients) and central retinal vein occlusion (CRVO) (on more than 1000 patients). Based on those studies, I can only conclude that this hypothesis is based more on armchair philosophy than scientific facts. Thomas Henry Huxley said, "The great tragedy of Science - the slaying of a beautiful hypothesis by an ugly fact." But what we need to find out is if the hypothesis is based on facts. In the space allowed for a letter to the editor, I cannot discuss the subject in . . . [Full Text of this Article]
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RELATED ARTICLE
Hypothesis: A Venous Etiology for Nonarteritic Anterior Ischemic Optic Neuropathy
Leonard A. Levin and Helen V. Danesh-Meyer
Arch Ophthalmol. 2008;126(11):1582-1585.
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RELATED LETTER
Pathogenesis of Nonarteritic Anterior Ischemic Optic Neuropathy—Reply
Leonard A. Levin and Helen V. Danesh-Meyer
Arch Ophthalmol. 2009;127(8):1083-1084.
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