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A Summary of Findings From the Optic Neuritis Treatment Trial

Roy W. Beck, MD, PhD; Robin L. Gal, MSPH

Arch Ophthalmol. 2008;126(7):994-995.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Corticosteroids have been used as treatment for optic neuritis since these drugs were introduced into clinical practice in the 1950s. Numerous anecdotal reports and clinical experience suggested that they were effective but early randomized trials did not demonstrate a benefit, although they were all inconclusive because of small sample size. In the 1980s, the Optic Neuritis Treatment Trial was developed to evaluate corticosteroid treatment for optic neuritis. This multicenter randomized clinical trial, supported by the National Eye Institute, was designed to answer the following questions: (1) Does treatment with either oral prednisone or intravenous methylprednisolone followed by oral prednisone improve the visual outcome of acute optic neuritis? (2) Does either treatment speed recovery of vision? and (3) Are the complications of treatment insignificant in relation to the magnitude of the treatment effect? Long-term follow-up of the cohort was performed to investigate . . . [Full Text of this Article]

STUDY DESIGN


RESULTS

CONCLUSIONS

AUTHOR INFORMATION
Author Affiliations: Jaeb Center for Health Research, Tampa, Florida.

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The Optic Neuritis Treatment Trial: A Definitive Answer and Profound Impact With Unexpected Results
Nicholas J. Volpe
Arch Ophthalmol. 2008;126(7):996-999.
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