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Risk Factors for Normal-Tension Glaucoma Among Subgroups of Patients
Sung Chul Park, MD;
Dong Hoon Lee, MD;
Hyun Joo Lee, MD;
Changwon Kee, MD, PhD
Arch Ophthalmol. 2009;127(10):1275-1283.
Objective To identify risk factors for normal-tension glaucoma among subgroups of patients.
Methods In 93 patients with unilateral normal-tension glaucoma, intereye comparison of baseline spherical equivalent, central corneal thickness, untreated intraocular pressure, disc area, and zone β variables was performed among the following 4 subgroups classified according to age and visual field pattern standard deviation of the eye with glaucoma: subgroup 1 (age  50 years and visual field pattern standard deviation 8 dB), subgroup 2 (50 years and >8 dB), subgroup 3 (>50 years and 8 dB), and subgroup 4 (>50 years and >8 dB).
Results Fourteen, 27, 30, and 22 patients were included in subgroups 1, 2, 3, and 4, respectively. The untreated intraocular pressure in subgroup 1 (P = .005), the zone β variables in subgroup 2 (P < .001), and both the untreated intraocular pressure (P = .010 and P = .034, respectively) and the zone β variables (P .008 and P .006, respectively) in subgroups 3 and 4 were significantly greater in the eyes with glaucoma than in the normal contralateral eyes (by paired t test or Wilcoxon signed rank test). The other variables showed no significant difference between the eyes in any subgroup.
Conclusion The zone β variables (and not the untreated intraocular pressure) may represent significant risk factors in young patients having normal-tension glaucoma with moderate to severe visual field loss.
Author Affiliations: Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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